IPD meta-analysis to show “highest level of evidence” for EVAR vs. open repair


Principal investigators: Roger Greenhalgh, Jan Blankensteijn, Jean-Pierre Becquemin and Frank Lederle.

An Individual Patient Data (IPD) meta-analysis of the randomised controlled trials—EVAR 1, DREAM, ACE and OVER—will show the “highest level of evidence” of endovascular aneurysm repair against open repair for abdominal aortic aneurysms, according to Roger Greenhalgh, chairman of the CX Symposium Programme Organising Board.

The meta-analysis, to be presented for the first time at CX in the Abdominal Aortic Aneurysm Challenges Day (Wednesday, 27 April), shows how the data of the four trials have been merged over the years of follow-up. “Putting the patient data from the four trials together increases the power for analysis and key lessons are learned from this study,” comments Greenhalgh, principal investigator of the IPD meta-analysis.

The data from the EVAR 1 Trial (Roger Greenhalgh), DREAM (Jan Blankensteijn), ACE (Jean-Pierre Becquemin) and OVER (Frank Lederle) were merged at Imperial College in London, UK, and are being analysed at the University of Cambridge Statistical Unit.

The CX Abdominal Aortic Aneurysm Challenges Day will take place at the Charing Cross Symposium on Wednesday 27 April – Upper Main Auditorium, Olympia Grand, London, UK

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